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It is common practice in the UK to give an arbitrary histological score to ovarian tumours in different tumour boards. However, this practice has two disadvantages. It does not use all of the available information and it ignores the fact that some tumours are of low grade and others are of high grade. This paper suggests a grading system which would be based on a) the WHO classification of ovarian tumours; b) an assessment of the biological potential of the tumour and c) the influence of age on tumour prognosis. It shows how such a system can be used to predict survival. Patients with tumours of low grade are predicted to do as well as patients with tumours of high grade. Survival rates are similar for patients with grade 3 tumours to those with low grade tumours in the other grades of tumour.Functions of spermine in osmotically stressed Tetrahymena pyriformis GL: induction of free radicals and nucleic acid fragmentation.
The effects of spermine on the biochemical changes during osmotic stress in Tetrahymena pyriformis GL were studied. A concentration-dependent increase in spermine-stimulated (0-1000 microM) DNA fragmentation occurred at osmostress (0.5 M NaCl) and upon incubation of spermine-containing cells with osmotically stressed (0.6 M NaCl) cells. Formation of free radicals as judged by ESR and uridine incorporation into RNA were also increased. These results suggest that spermine is a factor mediating nucleic acid damage at osmotic stress./* global describe, it, beforeEach, afterEach, expect */